Swimming Exercise Protects against Insulin Resistance via Regulating Oxidative Stress through Nox4 and AKT Signaling in High-Fat Diet-Fed Mice

Figure 1

Evaluation of insulin resistance. (a) IGTT curves of mice in each group. (b) IITT curves of mice in various groups. (c) The fasting blood glucose in three groups at the 8^th week. There were no significant differences in the fasting blood glucose measured after an 8-week swimming exercise intervention compared with the untreated high-fat diet group. (d) The fasting blood insulin in three groups at the 8^th week. There was a significant decrease in the fasting blood insulin that was measured after an 8-week swimming exercise intervention compared with the untreated high-fat diet group. (e, f) HOMA-IR and ISI values of different groups at the 8^th week, which were also selected to evaluate IR. After training with swimming exercise, HOMA-IR and ISI were both improved. Data are presented as . versus the CON group; ^## versus the HFD group. ^@@ versus the CTL group; ^△△ versus the m-hNox4^Tg group.

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