Journal of Diabetes Research / 2018 / Article / Tab 3 / Research Article
Retinopathy, Neuropathy, and Subsequent Cardiovascular Events in Patients with Type 2 Diabetes and Acute Coronary Syndrome in the ELIXA: The Importance of Disease Duration Table 3 Predictors of retinopathy and neuropathy multivariate models.
Parameter Retinopathy Neuropathy OR (95% CI) scoreOR (95% CI) scoreDuration of diabetes (per 5 years) 1.48 (1.41–1.56) 14.64 1.31 (1.25–1.37) 11.52 Insulin use 2.77 (2.23–3.46) 9.13 2.19 (1.86–2.58) 9.36 Weight (per 5 kg) — — 1.09 (1.07–1.11) 8.83 Previous PCI 0.75 (0.61–0.91) 2.94 0.60 (0.51–0.70) 6.32 Total cholesterol (per 10 mg/dl) — — 1.05 (1.04–1.07) 6.23 History of PAD — — 1.88 (1.45–2.43) 4.82 History of HF 1.65 (1.35–2.02) 4.82 1.32 (1.12–1.56) 3.23 Previous stroke 2.06 (1.51–2.82) 4.54 1.86 (1.42–2.45) 4.45 Diastolic blood pressure (per 10 mmHg) — — 0.88 (0.82–0.95) 3.25 Sulphonylurea use — — 1.29 (1.11–1.51) 3.24 Previous CABG 0.72 (0.52–0.98) 2.11 0.66 (0.51–0.86) 3.06 Presence of hypertension 1.46 (1.11–1.91) 2.69 1.39 (1.12–1.72) 3.00 Body mass index (per 5 kg/m2 ) 1.12 (1.04–1.22) 2.99 — — Glucose (per 10 mg/dl) 1.02 (1.0-1.04) 2.29 1.02 (1.01–1.03) 2.87 eGFR (per 10 ml/min/1.73m2 ) 0.94 (0.90–0.98) 2.66 — — Male sex — — 1.25 (1.06–1.47) 2.60 HDL cholesterol (per 10 mg/dl) 1.11 (1.02–1.20) 2.53 — — Age (per 5 years) — — 1.05 (1.01–1.10) 2.20 HbA1c (per 1%) 1.09 (1.00–1.19) 1.98 — —
Model AUC = 0.81 (retinopathy) and model AUC = 0.76 (neuropathy). HF: heart failure; PCI: percutaneous coronary intervention; eGFR: estimated glomerular filtration rate; HDL: high-density lipoprotein; CABG: coronary artery bypass grafting; HbA1c: glycated hemoglobin; PAD: peripheral artery disease.