Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children
Table 1
Characteristics of participating children at start and end point of the 1-year intervention period. Characteristics are shown for all obese children (), children with substantial weight loss (WL, ), and children without substantial weight loss (nWL, ) as mean ± SD unless stated otherwise.
Parameter
All start (%)
All end (%)
WL start (%)
WL end (%)
nWL start (%)
nWL end (%)
Sex, male
36 (45%)
18 (45%)
18 (45%)
Age (years)
11.5 ± 2.42
12.5 ± 2.42
10.6 ± 2.54
11.6 ± 2.54
12.4 ± 1.9
13.4 ± 1.9
Prepubertal
34 (42%)
26 (32%)
23 (58%)
18 (45%)
11 (28%)
8 (20%)
Early pubertal
42 (52%)
44 (55%)
17 (42%)
22 (55%)
25 (62%)
22 (55%)
Postpubertal
4 (5%)
10 (12%)
—
—
4 (10%)
10 (25%)
BMI-SDS
2.4 ± 0.45
2.1 ± 0.63
2.4 ± 0.44
1.7 ± 0.58
2.4 ± 0.46
2.4 ± 0.47
Waist circumference (cm)
91.7 ± 14
89.3 ± 13.89
87 ± 13.59
81 ± 10.99
96.5 ± 12.88
97.3 ± 11.55
Insulin (mU/L)
19.9 ± 15.01
17 ± 12.39
18 ± 12.01
9.3 ± 3.87
21.9 ± 17.44
25.1 ± 13.14
Fasting glucose (mg/dL)
86.3 ± 7.38
87.1 ± 6.39
84.8 ± 7.05
85.5 ± 5.76
87.8 ± 7.47
88.8 ± 6.65
2-hour oGTT glucose (mg/dL)
132.7 ± 25.02
113.9 ± 23.94
133.9 ± 24.26
98.9 ± 10.42
131.4 ± 25.99
128.9 ± 24.28
HbA1C (mmol/mol Hb)
373.43 ± 32.92
372.81 ± 37.98
364.16 ± 30.12
363.77 ± 30.81
382.95 ± 33.32
382.61 ± 42.78
HOMA
4.29 ± 3.1
3.79 ± 3.2
4.01 ± 3
1.96 ± 0.81
4.58 ± 3.21
5.67 ± 3.64
Significant different means between start and end point (, paired Wilcoxon rank sum test).
