Tyrosine Is Associated with Insulin Resistance in Longitudinal Metabolomic Profiling of Obese Children

Figure 3

Manhattan plot for associations of amino acids (AA) and acylcarnitines (Carn) with HOMA after the one-year lifestyle intervention for all obese children (a), children with substantial weight loss (b), and children without substantial weight loss (c). Plotted are the values and the sign is used to indicate the direction of the relationship, as assessed by the robust regression model. The area below or above the dashed lines contains metabolites that are significantly related to HOMA ( values < 0.05). AAA, aromatic amino acids; BCAA, branched-chain amino acids.

(a)

(b)

(c)