Genetic Associations of PPARGC1A with Type 2 Diabetes: Differences among Populations with African Origins
Table 4
(a) PPARGC1A SNP association with T2D in Haitian Americans. (b) PPARGC1A SNP association with T2D in African Americans.
(a)
Variables
Haitian American
Unadjusted OR
95% CI
value
Adjusted OR
95% CI
value
rs8192678
TT + CT versus CC
0.66
0.30
1.42
0.285
0.49
0.15
1.60
0.228
rs7656250
CC + CT versus TT
0.66
0.34
1.30
0.231
0.22
0.07
0.64
0.005
rs4235308
CC + CT versus TT
0.53
0.30
0.95
0.033
0.42
0.17
0.93
0.026
rs11724367
CC + CG versus GG
1.14
0.52
2.52
0.745
1.73
0.55
5.49
0.353
rs8192678 sex
—
—
—
—
—
1.77
0.34
9.27
0.490
rs7656250 sex
—
—
—
—
—
7.53
1.66
34.15
0.008
rs4235308 sex
—
—
—
—
—
1.56
0.46
5.34
0.444
rs11724367 sex
—
—
—
—
0.54
0.09
2.95
0.483
Note: the statistically significant results are in bold. Controlled variables included in the logistic regression analysis for adjusted OR were age, sex, BMI, and smoking status. The interactions between sex and individual SNP were also included in logistic regression analysis for all the SNP. is considered significant at 0.05. OR: odds ratio; CI: confidence interval; PPARGC1A: peroxisome proliferator activated receptor, gamma, coactivator 1 alpha.
(b)
Variables
African American
Unadjusted OR
95% C.I.
value
Adjusted OR
95% C.I.
value
rs8192678
TT + CT versus CC
0.90
0.45
1.87
0.777
0.55
0.19
1.56
0.269
rs7656250
CC + CT versus TT
0.62
0.34
1.13
0.117
1.02
0.43
2.43
0.940
rs4235308
CC + CT versus TT
1.29
0.75
2.21
0.356
2.53
1.08
5.92
0.028
rs11724367
CC + CG versus GG
0.69
0.33
1.25
0.329
0.29
0.08
1.14
0.073
rs8192678 sex
—
—
—
—
—
1.46
0.38
5.60
0.585
rs7656250 sex
—
—
—
—
—
0.36
0.11
1.13
0.079
rs4235308 sex
—
—
—
—
—
0.48
0.15
1.59
0.220
rs11724367 sex
—
—
—
—
—
3.78
0.82
17.31
0.082
Note: the statistically significant results are in bold. Controlled variables included in the logistic regression analysis for adjusted OR were age, sex, BMI, and smoking status. The interactions between sex and individual SNP were also included in logistic regression analysis for all the SNP. is considered significant at 0.05. OR: odds ratio; CI: confidence interval; PPARGC1A: peroxisome proliferator activated receptor, gamma, coactivator 1 alpha.
