Development of a Nongenetic Mouse Model of Type 2 Diabetes

Figure 6

Glucose tolerance test: (a) Fasting blood glucose concentrations at baseline and 15, 30, 60, and 120 min post-glucose loading via i.p. injection (2g⋅kg⁻¹BW), (b) interaction of diet and STZ treatment on total AUC calculated from glucose tolerance test data, (c) interaction of diet and STZ treatment on glucose clearance rate, calculated from 30 to 120 min post-glucose loading. Male, retired breeder (6 mo.) C57BL/6 mice were used for this study. Values represent mean ± SEM (𝑁=5–8). *𝑃<0.05 versus respective control, ^#𝑃<0.05 versus respective LFD group, ^‡𝑃=0.06 versus respective LFD group, ^†𝑃=0.06 versus respective control.

(a) Glucose tolerance test blood glucose levels

(b) Glucose tolerance test total AUC

(c) Glucose clearance test