Islet Specific Wnt Activation in Human Type II Diabetes

Figure 3

α-cell hyperplasia in type II diabetes and expression of Wnt4 in α-cells. Immunostaining of pancreas from nondiabetic (a), (c), and (e) and type II diabetic (b), (d), and (f) individuals demonstrates α-cell hyperplasia in type II diabetes (a) and (b) and expression of Wnt4 (red in (c)–(f)) predominantly in α-cells (c)–(f). Scale bar in (a) and (b) = 200 𝜇m and in (c)–(f) = 50 𝜇m.

(a)

(b)

(c)

(d)

(e)

(f)