The Characterization of High-Fat Diet and Multiple Low-Dose Streptozotocin Induced Type 2 Diabetes Rat Model

Table 5

The biochemical parameter and ISI in the groups of the third section.

Group	CON3	C-STZ	HFD	HFD-STZ	BER
𝑁	20	20	20	17	17
Body weight (g)	415.6±11.8	397.9±14.2	477.3±23.1^*Δ	382.1±17.3	368.6±19.8
FBG (mmol/L)	4.49±0.41	5.25±0.44	5.56±0.52	14.79±0.32^**	6.48±0.56Δ
FINS (mU/L)	11.03±1.68	12.04±0.26	19.64±6.83^*	9.17±1.34	10.04±0.91
ISI	−3.87±0.15	−3.93±0.20	−4.69±0.21^*	−4.87±0.15^*	−3.68±0.09Δ
TG (mmol/L)	0.66±0.09	0.63±0.08	1.91±0.33^**	1.70±0.21^**	0.96±0.17^*Δ
TC (mmol/L)	1.72±0.11	1.78±0.19	3.35±0.26^**	2.99±0.53^**	2.67±0.58^*

CON3: control group; C-STZ: regular chow feed group with STZ 30 mg/kg twice IP; HFD: high-fat diet group; HFD-STZ: model group by high-fat diet with STZ 30 mg/kg twice IP; BER: berberine treatment group; FBG: fasting blood glucose; FINS: fasting blood insulin; ISI = ln(FBG×FINS)⁻¹; TG: triglyceride; TC: total cholesterol. Values are means ± SE, ^**𝑃<.01, ^*𝑃<.05 versus control group, Δ𝑃<.05 versus HFD-STZ group.