Segmental Arterial Mediolysis: A Multiguised Vasospastic Arteriopathy with Collateral Mesangial Cell Hyperplasia and Cardiac Toxicity Generated by Norepinephrine and Hyperdense Adrenoceptors Alone or by Crosstalk with Other Pressor Agents

Figure 11

Segmental arterial mediolysis injurious phase. The arrow points to a segment of the artery showing transmural mediolysis with patchy loss of the internal elastica and intima alterations that will allow the watery medial contents to be evacuated into the blood stream creating the gaps illustrated in Figures 12 and 13. The expanded watery mediolytic contents have pushed the fibrin-lined adventitia outwards. Movat stain ×50 (adapted with permission from the American Journal of Surgical Pathology 13(7) copyright l989, Lippincott, Williams and Williams).