Effect of Transcriptional Regulator ID3 on Pulmonary Arterial Hypertension and Hereditary Hemorrhagic Telangiectasia

Table 1

ID3 and PAH & HHT described in the scientific literature.

ID3 Associated Study Title	Authors	Year	Disease
Dysregulated bone morphogenetic protein	Morty et al.	2007	PAH
signaling in monocrotaline-induced
pulmonary arterial hypertension
ID family protein expression and regulation	Lowery et al.	2010	PH
in hypoxic pulmonary hypertension
BMP induces EphrinB2 expression in	Kim et al.	2012	HHT
endothelial cells through an
Alk1-BMPRII/ActRII-ID1/ID3-dependent
pathway: implications for hereditary
hemorrhagic telangiectasia type II
Id proteins are critical downstream	Yang et al.	2013	PAH
effectors of BMP signaling in human
pulmonary arterial smooth muscle cells
Sex affects bone morphogenetic	Mair et al.	2015	PAH
protein type II receptor signaling in
pulmonary artery smooth muscle
cells
ID3 contributes to the acquisition of	Das et al.	2015	IPAH, PAH
molecular stem cell-like signature in
microvascular endothelial cells: its
implication for understanding microvascular
diseases
ID3, estrogenic chemicals, and the	Avecilla V.	2017	PAH, HHT
pathogenesis of tumor-like proliferative
vascular lesions
The role of ID3 and PCB153 in the	Doke MA.	2018	PAH
hyperproliferation and dysregulation of
lung endothelial cells