A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice

<table>Comparison of the cardiac function measured by echocardiography in untreated and CAWS treatment DBA/2 mice. CAWS treatment DBA/2 mice developed left ventricular dilution and dysfunction between six and seven week after CAWS administration (a). Echocardiography revealed a diffuse, severe reduction of contractility in the left ventricle after CAWS treatment. Left ventricular fractional shortening (LVFS) decreased from 71% to 38% (<svg height="11.375" id="M29" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x31"></use></g>
</svg>), and dilation of the left ventricular diastolic dimension (LVDd) was observed from 2.21 mm to 3.26 mm (<svg height="11.375" id="M30" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 58.712502 11.375" width="58.712502" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,11.112)"><use xlink:href="#x1D443"></use></g><g transform="matrix(.017,-0,0,-.017,15.582,11.112)"><use xlink:href="#x3C"></use></g><g transform="matrix(.017,-0,0,-.017,30.286,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,38.446,11.112)"><use xlink:href="#x2E"></use></g><g transform="matrix(.017,-0,0,-.017,42.321,11.112)"><use xlink:href="#x30"></use></g><g transform="matrix(.017,-0,0,-.017,50.481,11.112)"><use xlink:href="#x31"></use></g>
</svg>) (b); <svg height="11.125" id="M31" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 44.400002 11.125" width="44.400002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.862)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.862)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.862)"><use xlink:href="#x31"></use></g><g transform="matrix(.017,-0,0,-.017,36.168,10.862)"><use xlink:href="#x30"></use></g>
</svg> (untreated) and <svg height="11.225" id="M32" style="vertical-align:-0.1638pt" version="1.1" viewbox="0 0 36.237499 11.225" width="36.237499" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,10.963)"><use xlink:href="#x1D45B"></use></g><g transform="matrix(.017,-0,0,-.017,13.305,10.963)"><use xlink:href="#x3D"></use></g><g transform="matrix(.017,-0,0,-.017,28.008,10.963)"><use xlink:href="#x36"></use></g>
</svg> (CAWS treatment).</table>

International Journal of Vascular Medicine

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Figure 6

Figure 6: A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice 