A Model of Left Ventricular Dysfunction Complicated by CAWS Arteritis in DBA/2 Mice

Figure 4

Cardiomegaly and histopathological changes of the aortic root due to CAWS arteritis. Macroscopic cardiomegaly and concentric left ventricular hypertrophy were observed in the CAWS treatment group (a, b). The panels (c) represent enlarged views of each aortic valve. Inflammatory cells were located mainly in the aortic valve and Valsalva sinus, and severe stenosis of the left ventricular outflow tract (LVOT) was found in CAWS arteritis. There was no evidence of necrosis or fibrosis to indicate broad infarctions in the left ventricular wall. The cross sectional area of CAWS-treated cardiomyocyte was increased by 1.14 fold (d).