Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling

Figure 3

Effects of CNP on Ang II-induced myocardial interstitial fibrosis. (a) Representative images of Masson’s trichrome (MT) staining of heart sections. Scale bars: 100 μm. (b) Quantitative analysis of myocardial interstitial fibrosis in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. (c) Collagen I and III transcript expression in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. Results are mean ± SEM (𝑛=4–9 each). *𝑃<0.05.

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