Chronic C-Type Natriuretic Peptide Infusion Attenuates Angiotensin II-Induced Myocardial Superoxide Production and Cardiac Remodeling
Figure 2
Effects of CNP on Ang II-induced cardiomyocyte hypertrophy. (a) Representative images of hematoxylin-eosin- (H&E-) stained heart sections. Scale bars: 50 μm. (b) Heart weight to tibial length ratio (HW/TL) in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. (c) Quantitative analysis of cardiac myocyte cross-sectional area in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. Data were obtained from analysis of H&E-stained heart sections. (d) Lung weight to tibial length ratio (LW/TL) in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. (e) Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and β-myosin heavy chain (βMHC) transcript expression in vehicle- and CNP-treated mice 2 weeks after saline or Ang II infusion. Results are mean ± SEM (–9 each). *.
