Caffeates and Caffeamides: Synthetic Methodologies and Their Antioxidant Properties

Table 2

Lipid peroxidation inhibitory activity of caffeic acid amides and related compounds.

Entry	Compound	Structure	IC50 (µM)^a	Reference
1	N-(2-Hydroxyphenyl) caffeamide		0.29	[44]
2	N-Phenyl caffeamide		0.38	[44]
3	N-(3,4-Dihydroxyphenethyl) caffeamide		0.59	[44]
4	N-Isopentyl caffeamide		1.4	[44]
5	Trolox		2.8	[44]
6	Caffeic acid		3.3	[44]
7	Quercetin		0.95	[44]

^aThe antioxidant activity of each compound was expressed as IC₅₀ value, i.e., the concentration in µM necessary to inhibit TBARS formation by 50%, and was calculated from the corresponding log-dose inhibition curve.