Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors

<div>(a) CA IX and CA II and (b) CA XII activities were assessed using MIMS, under normoxic or hypoxic conditions for 16 h in the presence or absence of the impermeant sulfonamide inhibitor N-3500. DSF was used to determine the binding affinity of N-3500 to purified (c) CA II and (d) CA IX.</div>

International Journal of Medicinal Chemistry

fig3

Figure 3

Figure 3: Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors 

Figure 3 | Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors 