Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility

Table 3

(nm) and equilibrium solubility of tested compounds 5–10 at pH 1.2 and 6.8 buffer solutions.

Compound	(nm)		Mean solubility (μg/ml) ± SD
	pH 1.2	pH 6.8	pH 1.2	pH 6.8
1	292	292	12.32 ± 0.29	12.37 ± 0.26
3	294.5	295.6	11.13 ± 0.37	11.09 ± 0.82
5	294	294	14.26 ± 0.42	27.94 ± 0.27
6	294.5	291.5	14.86 ± 0.12	14.51 ± 0.39
7	293	294	31.49 ± 0.72	18.32 ± 0.46
8	294.5	295.8	29.13 ± 0.72	12.53 ± 0.54
9	292.5	293.5	13.97 ± 0.31	13.78 ± 0.07
10	290.5	294.6	26.67 ± 0.57	16.58 ± 0.58