Research Article
Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility
Table 3
(nm) and equilibrium solubility of tested compounds
5–
10 at pH 1.2 and 6.8 buffer solutions.
| Compound | (nm) | Mean solubility (μg/ml) ± SD | pH 1.2 | pH 6.8 | pH 1.2 | pH 6.8 |
| 1 | 292 | 292 | 12.32 ± 0.29 | 12.37 ± 0.26 | 3 | 294.5 | 295.6 | 11.13 ± 0.37 | 11.09 ± 0.82 | 5 | 294 | 294 | 14.26 ± 0.42 | 27.94 ± 0.27 | 6 | 294.5 | 291.5 | 14.86 ± 0.12 | 14.51 ± 0.39 | 7 | 293 | 294 | 31.49 ± 0.72 | 18.32 ± 0.46 | 8 | 294.5 | 295.8 | 29.13 ± 0.72 | 12.53 ± 0.54 | 9 | 292.5 | 293.5 | 13.97 ± 0.31 | 13.78 ± 0.07 | 10 | 290.5 | 294.6 | 26.67 ± 0.57 | 16.58 ± 0.58 |
|
|