Research Article
Design, Synthesis, and Cytotoxicity Evaluation of Novel Griseofulvin Analogues with Improved Water Solubility
Table 1
Interaction energies and in vitro cytotoxic activities of taxol, 5-fluorouracil, tamoxifen, griseofulvin 1, compound 3, and target compounds 5–10.
| Compound name/number | Isomer | (Kcal/mole) | IC50 (μM) against HCT116 | IC50 (μM) against MCF-7 |
| 5-Fluorouracil | — | n.t. | 19.50 | n.t. | Tamoxifen | — | n.t. | n.t. | 10.00 | Taxol | — | −7.9426 | n.t. | n.t. | Griseofulvin | — | −6.1399 | 35.50 | 69.00 | 3 | — | −6.9434 | 35.80 | 32.80 | 5 | | −7.0208 | >100 | 20.70 | | −7.1249 | 6 | | −6.6714 | 87.84 | 55.87 | | −6.6542 | 7 | | −6.7421 | 85.60 | 54.54 | | −6.7534 | 8 | | −7.2516 | 39.80 | 25.30 | | −7.2894 | 9 | | −7.3765 | 10.50 | 21.50 | | −7.3482 | 10 | | −7.4810 | 8.39 | 14.50 | | −7.5143 |
|
|
n.t.: not tested.
|