Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents

Table 8

Biological evaluation of compounds on Wistar rats.

Drug	Blood glucose level mg/dL (mean ± SE)
	0 hr	1 hr	3 hr	6 hr
Normal	90.667 ± 1.585	90.667 ± 1.585	92.00 ± 1.438	91.500 ± 1.996
1	201.333 ± 4.379	137.333 ± 2.963	123.667 ± 3.461	112.833 ± 4.909
2 (CID 20269015)	201.833 ± 4.778	167.833 ± 3.468	151.00 ± 2.098	139.833 ± 2.358
3	198.333 ± 9.584	155.167 ± 3.321	136.833 ± 2.197	125.00 ± 4.139
4	198.667 ± 2.629	151.500 ± 1.648	125.833 ± 1.887	107.333 ± 3.658
5	190.00 ± 5.471	226.667 ± 28.273	215.167 ± 10.150	210.00 ± 3.873
6	200.00 ± 7.038	204.667 ± 7.292	225.333 ± 5.719	235.833 ± 4.527
Diabetic control	206.167 ± 5.747	210.667 ± 4.364	212.00 ± 4.494	229.667 ± 5.942
Metformin	201.167 ± 2.120	127.333 ± 3.621	114.833 ± 3.219	110.500 ± 1.607