Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents

Table 7

H-bonding interactions and G-score results of docking studies of designed molecules.

Compound	H-bond		Number of H-bonds	G-score
	Amino acid	Distance (Å)
1	Ser342	2.019	2	−8.04
	Glu343	2.126
3	His446	2.233	1	−7.23
4	Ser342	2.489	1	−7.29
5	Met364	2.962	1	−8.02
6	Ser342	2.047	2	−7.25
	Glu343	2.175
Rosiglitazone	Ser342	2.827	1	−9.94