Design and Synthesis of Pyrazole-3-one Derivatives as Hypoglycaemic Agents

Table 2

Reported antidiabetic pyrazole-4-carboxylic acid compounds used for docking studies.

Reference compound	R1	R2
R4	H	H
R5	CH3	H
R6	2-CN-[1,1′-biphenyl]-4′-(CH2)	H
R7	CH3	(CH3)2C=CH-CH2
R8	C6H5CH2	CH3CH2OOC-(CH2)3
R9	C6H5CH2	Tetrazole-CH2
R10	H	CH3

See Scheme 2.