Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
Figure 2
Photograph presentation of histological change of dysplasia in the bowels taken from ICR mice dosed with DMH and DSS over the examined time-points. The images from H&E stained slides showed that tumors were not observed in the controls (Figure 2(a)). However, dysplastic lesion was observed after induction for 14 weeks (arrow pointed in Figure 2(b)); the degree of dysplasia was further increased after induction for 16 weeks (arrow pointed in Figure 2(c)) and 18 weeks (arrow pointed in Figure 2(d)) and finally became cancerous lesion after the induction of 22 weeks (arrow pointed in Figure 2(e)) (Figures 1(a)–1(e): images from H&E stained slides, original magnification ×200).
