Research Article
Cognitive Impairment among Cardiac Arrest Survivors in the ICU: A Retrospective Study
Table 4
Comparison of serum biomarkers between patients with and without cognitive impairment (n = 53).
| | | First cognitive assessment | Last cognitive assessment | | MMSE ≥ 24 (n = 12) | MMSE < 24 (n = 41) | | MMSE ≥ 24 (n = 35) | MMSE < 24 (n = 18) | |
| | NSE 0 h, ng/mL (n = 48) | 22.03 (15.30–31.52) | 18.59 (15.08–22.80) | 0.206 | 19.09 (13.84–23.05) | 20.05 (16.85–26.66) | 0.301 | | NSE 24 h, ng/mL (n = 45) | 19.94 (15.67–24.10) | 19.20 (15.16–22.27) | 0.653 | 17.86 (14.95–21.80) | 21.40 (18.02–26.19) | 0.030 | | NSE 48 h, ng/mL (n = 37) | 11.27 (7.66–17.48) | 12.40 (8.17–17.33) | 0.604 | 11.58 (7.98–17.44) | 15.20 (7.86–17.29) | 0.425 | | NSE 72 h, ng/mL (n = 23) | 9.70 (8.01–19.86) | 11.29 (10.51–12.90) | 0.804 | 10.78 (8.30–13.85) | 13.64 (11.09–13.65) | 0.315 | | S100B 0 h, ng/mL (n = 51) | 0.27 (0.18–1.62) | 0.29 (0.15–0.95) | 0.464 | 0.23 (0.17–0.67) | 0.37 (0.15–1.75) | 0.411 | | S100B 24 h, ng/mL (n = 51) | 0.08 (0.06–0.09) | 0.09 (0.06–0.11) | 0.484 | 0.07 (0.05–0.10) | 0.09 (0.07–0.13) | 0.022 | | S100B 48 h, ng/mL (n = 46) | 0.07 (0.06–0.10) | 0.10 (0.06–0.12) | 0.395 | 0.07 (0.06–0.11) | 0.11 (0.08–0.15) | 0.009 | | S100B 72 h, ng/mL (n = 25) | 0.07 (0.04–0.08) | 0.06 (0.04–0.09) | 0.912 | 0.06 (0.04–0.08) | 0.08 (0.06–0.11) | 0.111 |
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MMSE, Mini-Mental State Examination; NSE, neuron-specific enolase; S100B, S100 calcium-binding protein B.
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