Herbal Extracts Combination (WNK) Prevents Decline in Spatial Learning and Memory in APP/PS1 Mice through Improvement of Hippocampal Aβ Plaque Formation, Histopathology, and Ultrastructure

Figure 3

Immunofluorescent micrographs of amyloid plaques (×400). (a) Nontransgenic group; (b) transgenic group; (c) WNK group; (d) EGB761 group; (e) Aβ-immunoreactivity intensity of amyloid plaques. Significant Aβ plaques (arrows) can been seen in CA1 hippocampal neurons of an 8-month-old APP/PS1 mice (Figure 3(b)) while are occasionally found in those of wide-type littermate mice at the same age (Figure 3(a)). Overexpression of Aβ reduce after 3-month WNK or EGBA761 treatment (Figures 3(c), 3(d), and 3(d)). Note: ^###𝑃<0.001, compared with nontransgenic group; *𝑃<0.05, compared with transgenic group.

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