Cardiovascular disease is the leading cause of mortality worldwide, being responsible for 31% of all deaths. Since the last century, enormous pharmacological targets and related drugs separately originated from proteomics, genomics, and transcriptomics have been identified and partially translated into clinical therapy for cardiovascular diseases. However, huge research gaps and clinical challenges still exist in the understanding of the pathophysiology, prevention, and treatment of cardiovascular disease. Accumulating evidence highlights that the factors from proteomics, genomics, and transcriptomics may cooperatively contribute to cardiovascular disorder, leading to the pathogenesis and progress of cardiovascular disease.

Over the past two to three decades with the development of next-generation sequencing technologies, non-coding RNAs (ncRNA) such as microRNAs (miRNA), long non-coding RNAs (lncRNA), and circular RNAs (circRNA) have been assessed as powerful regulators of nearly all biological processes by exerting epigenetic, transcriptional, or translational control of target genes. It has been recognized that ncRNAs play a pivotal role in cardiovascular disease in a delicate and sophisticated network modulation manner. Identification of ncRNAs and exploring their underlying mechanism sheds new insight into elucidating the pathophysiology of cardiovascular disease and provide possible new precise diagnostic biomarkers or potential therapeutic targets for cardiovascular disease.

The aim of this Special Issue is to collect original articles in the field of ncRNAs that will contribute prominently to cardiovascular disease research. We aim to gather papers interrogating the mechanisms or clinical translations of ncRNAs underlying cardiovascular disease, including, but not limited to, coronary artery disease, hypertension, heart failure, and acute myocardial infarction. Both original research and review articles are welcome.

Potential topics include but are not limited to the following:

• ncRNAs biomarkers for cardiovascular disease
• Gene polymorphisms of ncRNAs related to cardiovascular disease susceptibility
• Associations between cardiovascular diseases and disorder of diet, exercise, and intestinal microbiota
• Bioinformatic analyses of ncRNAs in the prevention, treatment, diagnosis and prognosis of cardiovascular disease
• ncRNAs and cardiovascular disorder
• Potential ncRNAs targets and drug treatments of cardiovascular disease