Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia

Table 5

Effect of Lavandula angustifolia on seizures induced by pentylenetetrazol (PTZ) in mice.

Treatment	Dose (mg/kg)	Seizure latency (sec)	Tonic-clonic onset (sec)	Seizure duration (sec)	Death time (sec)	Mortality protection (%)
Normal saline	10 ml/kg					0
Diazepam	2 mg/kg	—	—	—	—	100
L. angustifolia	200 mg/kg					40
	400 mg/kg					10
	600 mg/kg				—	90
	800 mg/kg					60
value	—	0.001^#	0.001^+	0.000^#	0.002^#	—
Test statistic	—	18.918^#	5.445^+	20.659^#	17.503^#	—

^aNormal saline, diazepam, and L. angustifolia were administered 30 minutes prior to PTZ injection (90 mg/kg). ^# values and test statistics () refer to the Kruskal-Wallis test. ⁺ values and test statistics () refer to one-way ANOVA test. and compared with the normal saline group; refer to the post hoc tests (Dunn’s test for the Kruskal-Wallis test and Tukey’s test for one-way ANOVA).