Antiseizure Effects of Peganum harmala L. and Lavandula angustifolia

Table 2

Effects of Peganum harmala L. on seizures induced by pentylenetetrazol (PTZ) in mice^a.

Treatment	Dose	Seizure latency (sec)	Tonic-clonic onset (sec)	Seizure duration (sec)	Death time (sec)	Mortality protection rate (%)
Normal saline	10 ml/kg					0
Diazepam	2 mg/kg	—	—	—	—	100
Peganum harmala	2.5 mg/kg					60
	5 mg/kg					60
	10 mg/kg				—	90
	15 mg/kg					20
	30 mg/kg					10
	45 mg/kg					10
	60 mg/kg					0
value	—	0.000^#	0.000^#	0.000^#	0.003^#	—
Test statistic	—	43.393^#	27.638^#	42.330^#	21.730^#	—

^aNormal saline, diazepam, and Peganum harmala L. were administered 30 minutes prior to PTZ injection (90 mg/kg). ^# values and test statistics () refer to the Kruskal-Wallis test and assess differences in each variable among studied groups. and compared with the normal saline group; refer to the post hoc tests (Dunn’s test).