Research Progress of m⁶A RNA Methylation in Skin Diseases

Figure 3

Process of m⁶A methylation induced by UVB and arsenic in skin. Several m⁶A regulators, including methylation on writing protein METTL3, methylation reading protein YTHDF1, and demethylase FTO, play an important role in the development of melanoma, even skin mutation and canceration to causing cSCC especially after UVB and arsenic exposure. FTO regulates NEDD4L mRNA stability to promote skin neoplasms via IGF2BPs. METTL3 increases inflammatory factor secretion including IL-6, IL-17, and IL-10 in human keratinocytes; then, KRT1 and KRT10 reflecting skin injury are also significantly elevated. METTL3 also enhanced ΔNp63 expression in cSCC. METTL14 facilitates GGR to suppress UVB-induced skin tumorigenesis. YTHDF1 activates cap-dependent translation. Then, the translation initiation factors eIF3A and eIF3B cooperate synergistically to possibly lead to high tumorigenicity in MCC.