Research Progress of m⁶A RNA Methylation in Skin Diseases

Figure 1

The types and roles of enzymes in dynamic modification of m⁶A methylation. The m⁶A RNA methylation is dynamically regulated by writers, erasers, and readers to add, remove, or recognize m⁶A, respectively. Writers include METTL3, METTL5, METTL14, METTL16, WTAP, RBM15/15B, and ZC3H13. Erasers, FTO and ALKBH5, are two known demethylases. Readers are proteins that recognize the m⁶A sites and perform multiple functions in nucleus or cytoplasm, including YTHDF1, YTHDF2, YTHDF3, YTHDC1, YTHDC2, HNRNPC, HNRNPG, and IGF2BPs. These enzymes are involved in RNA splicing, translation, structure switching, and RNA decay during m⁶A RNA methylation.