Pantoprazole-Induced Bone Loss through Gastrin Secretion: A Stereological Study

Figure 5

Qualitative analysis of the osteocytes, osteoblasts, and osteoclast cells of the femur tissue in the experimental groups (hematoxylin and eosin staining with ×400 magnification). (a) Healthy control group, (b) octreotide group, (c) Pan group, and (d) Pan+Oct group. The results showed a significant decrease in the number of osteocytes and bone lacuna depletion (pick arrow) in the Pan group compared to the control and Oct groups. A significant increase was also observed in the number of osteoclast cells in the Pan group compared to the other groups. However, no significant changes were detected in the number of osteoblast cells in the experimental groups.