The Use of Customized Three-Dimensionally Printed Mandible Prostheses with a Pressure-Reducing Device: A Finite Element Analysis in Different Chewing Positions, Biomechanical Testing, and In Vivo Animal Study Using Lanyu Pigs

Table 9

Comparison of histopathological results between CMP and HDPE.

Implantation interval	3 months
Group	CMP site				Control HDPE
Animal number	2393-03-R	2397-04-R	2395-01-R	2398-02-R	2393-03-L	2397-04-L	2395-01-L	2398-02-L
Inflammation	Score
Polymorphonuclear	1	0	0	1	1	1	1	1
Lymphocytes	1	1	1	1	1	2	2	2
Plasma cells	0	0	0	0	0	0	0	0
Macrophages	0	0	0	0	0	1	0	0
Giant cells	0	0	0	0	0	0	0	0
Necrosis	0	0	0	0	0	0	0	0
Subtotal (×2)	4	2	2	4	4	6	6	6
Neovascularization	1	1	0	1	1	1	0	1
Fibrosis	3	2	2	1	2	3	2	2
Fatty infiltration	0	0	0	2	0	0	0	0
Subtotal	4	3	2	4	3	4	2	3
Total	8	5	4	8	7	10	8	9
Group total^b	25				34
Average^a	6.3				8.5
Traumatic necrosis	0	0	0	0	0	0	0	0
Foreign body debris	0	0	0	0	0	0	0	0
No. of sites examined	1	1	1	1	1	1	1	1

^aAverage is the sum of scores among groups/numbers of recognizable implantation sites. Used to determine irritation ranking, which is shown below and served as the conclusion. A negative difference was coded as 0. ^bGroup total is the sum of scores among groups. Rating score is minimal or no reaction: 0.0–2.9; slight reaction: 3.0–8.9; moderate reaction: 9.0–15.0; and severe reaction: ≥15.1.