Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy

<div>Identification of DEGs specifically implicated in tubulointerstitial injury in DN. (a) Venn diagram of merge of GSE30529-GPL571, GSE47184-GPL11670, and GSE47184-GPL14663, the two datasets showed an overlap of 10859 genes. (b–d) The density (b), UMAP (c), and boxplot (d) figure before or after removing batch. (e) Volcano plot analysis identifies DEGs, <span class="nowrap"><svg height="12.1567pt" id="M21" style="vertical-align:-3.40336pt" version="1.1" viewbox="-0.0498162 -8.75334 72.2678 12.1567" width="72.2678pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M495 163C480 117 462 85 444 65C421 39 387 34 332 34C290 34 256 36 236 47C218 57 213 77 213 131V526C213 612 222 616 301 622V650H40V622C122 616 128 611 128 526V126C128 41 120 34 36 28V0H489C498 31 519 126 525 157L495 163Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.111,0)"><path d="M257 449C165 449 37 374 37 209C37 98 119 -12 256 -12C355 -12 473 65 473 226C473 349 381 449 257 449ZM244 416C333 416 380 320 380 204C380 67 329 21 267 21C184 21 130 115 130 241C130 354 184 416 244 416Z"></path></g><g transform="matrix(.013,0,0,-0.013,13.742,0)"><path d="M463 437C426 431 375 425 327 422C297 440 264 449 231 449H230C153 449 51 396 51 283C51 215 94 168 139 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550Z"></path></g></svg>.</span> (f) Heat map of the top 20 upregulated and top 20 downregulated DEGs. Red: upregulation; blue: downregulation.</div>

BioMed Research International

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Figure 2

Figure 2: Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy 

Figure 2 | Integrated Analysis of Multiple Microarray Studies to Identify Core Gene-Expression Signatures Involved in Tubulointerstitial Injury in Diabetic Nephropathy 