Research Article
Drifts in N-Linked Glycosylation Result in ADCC Potency Variation of Perjeta® from August 2020 to October 2021 in China
Figure 3
The influences of the drifts in %afucose on the ADCC activity. (a) ADCC activity of three typical batches of Perjeta® based on reporter gene assay, in which curves are unparalleled. (b) Relative maximum response shows the same drift trend as %afucose. (c) Correlation analysis between the %afucose and ADCC relative EC50. (d) Correlation analysis between the %afucose and the relative maximum response. The correlation between %afucose and %maximum response is higher than the correlation between %afucose and EC50.
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