Helicobacter bilis Contributes to the Occurrence of Inflammatory Bowel Disease by Inducing Host Immune Disorders

Table 1

Helicobacter bilis-induced inflammatory bowel disease.

Author	H. bilis	Research subjects	Mechanisms	Type of immunity	Year
Seamons et al. [9]	Not mentioned	Smad3^-/- mice	Not mentioned	Adaptive immunity	2020
Gomes-Neto et al. [42]	Not mentioned	C3H/HeN mice	Triggering CD4^+ Th17 cell immunoreactivity against specific member of microbiota, but not toward itself	Adaptive immunity	2017
Atherly et al. [43]	ATCC strain 51630	C3H/HeN mice	Altering mucosal bacteria	Adaptive immunity	2016
Javed et al. [44]	ATCC strain 43879	Colon cancer cell lines HCT116 (CCL-247), DLD-1 (CCL-221), and LS174T (CCL-188)	HBgGT enhances inflammatory stress ROS in colon epithelial cells	Adaptive immunity	2013
Muthupalani et al. [45]	Not mentioned	BALB/c mice	Macrophages are critical inflammatory cellular mediators for promoting H. bilis-induced IBD	Innate immunity	2012
Liu et al. [46]	ATCC strain 51630	C3H/HeN mice	Altering mucosal homeostasis and initiating immune cell activation and migration	Adaptive immunity	2011
Liu et al. [47]	Not mentioned	C3H/HeN mice	Inducing mucosal gene expression changes	Adaptive immunity	2009
Jergens et al. [48]	ATCC strain 51630	C3H/HeN mice	Triggering persistent immune reactivity to antigens derived from the commensal bacteria	Adaptive immunity	2007
Jergens et al. [49]	ATCC strain 51630	C3H/HeN mice	Induction of differential immune reactivity to members of the flora	Adaptive immunity	2006
Maggio-Price et al. [50]	Not mentioned	Mdr1a^-/- mice	Increased expression of inflammation markers/mediators (MHC class II, Cox-2, CD4, F4/80) and monokine (IL-1β, IL-1α)	Innate immunity	2005
Maggio-Price et al. [51]	Provided by Dr. Lela Riley	Mdr1a^-/- and FVB mice	Cytokine dysregulation (IFN-γ, TNF-α, IL-10)	Adaptive immunity	2002
Burich et al. [52]	Provided by Dr. Lela Riley	C57BL mice	Not mentioned (correlation analysis)	Not mentioned	2001
Haines et al. [53]	Not mentioned	Male athymic nude rat	Not mentioned (correlation analysis)	Not mentioned	1998
Shomer et al. [41]	ATCC strain 51630	SCID mice	Not mentioned (correlation analysis)	Not mentioned	1997

HBgGT: Helicobacter bilis gamma-glutamyltranspeptidase; ROS: response via oxidative stress.