Review Article
Helicobacter bilis Contributes to the Occurrence of Inflammatory Bowel Disease by Inducing Host Immune Disorders
Table 1
Helicobacter bilis-induced inflammatory bowel disease.
| Author | H. bilis | Research subjects | Mechanisms | Type of immunity | Year |
| Seamons et al. [9] | Not mentioned | Smad3-/- mice | Not mentioned | Adaptive immunity | 2020 | Gomes-Neto et al. [42] | Not mentioned | C3H/HeN mice | Triggering CD4+ Th17 cell immunoreactivity against specific member of microbiota, but not toward itself | Adaptive immunity | 2017 | Atherly et al. [43] | ATCC strain 51630 | C3H/HeN mice | Altering mucosal bacteria | Adaptive immunity | 2016 | Javed et al. [44] | ATCC strain 43879 | Colon cancer cell lines HCT116 (CCL-247), DLD-1 (CCL-221), and LS174T (CCL-188) | HBgGT enhances inflammatory stress ROS in colon epithelial cells | Adaptive immunity | 2013 | Muthupalani et al. [45] | Not mentioned | BALB/c mice | Macrophages are critical inflammatory cellular mediators for promoting H. bilis-induced IBD | Innate immunity | 2012 | Liu et al. [46] | ATCC strain 51630 | C3H/HeN mice | Altering mucosal homeostasis and initiating immune cell activation and migration | Adaptive immunity | 2011 | Liu et al. [47] | Not mentioned | C3H/HeN mice | Inducing mucosal gene expression changes | Adaptive immunity | 2009 | Jergens et al. [48] | ATCC strain 51630 | C3H/HeN mice | Triggering persistent immune reactivity to antigens derived from the commensal bacteria | Adaptive immunity | 2007 | Jergens et al. [49] | ATCC strain 51630 | C3H/HeN mice | Induction of differential immune reactivity to members of the flora | Adaptive immunity | 2006 | Maggio-Price et al. [50] | Not mentioned | Mdr1a-/- mice | Increased expression of inflammation markers/mediators (MHC class II, Cox-2, CD4, F4/80) and monokine (IL-1β, IL-1α) | Innate immunity | 2005 | Maggio-Price et al. [51] | Provided by Dr. Lela Riley | Mdr1a-/- and FVB mice | Cytokine dysregulation (IFN-γ, TNF-α, IL-10) | Adaptive immunity | 2002 | Burich et al. [52] | Provided by Dr. Lela Riley | C57BL mice | Not mentioned (correlation analysis) | Not mentioned | 2001 | Haines et al. [53] | Not mentioned | Male athymic nude rat | Not mentioned (correlation analysis) | Not mentioned | 1998 | Shomer et al. [41] | ATCC strain 51630 | SCID mice | Not mentioned (correlation analysis) | Not mentioned | 1997 |
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HBgGT: Helicobacter bilis gamma-glutamyltranspeptidase; ROS: response via oxidative stress.
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