Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants

Table 3

Risk estimates of gene-gene interactions on OW/OB in 12-month-old infants.

Terminal node (subtree group)	Genotype	OR (95% CI)
10	rs11030104 (AG/GG)- rs11191580 (CC/CT)- rs11165675 (GA/AA)- rs543874 (AA)	1
9	rs11030104 (AG/GG)- rs11191580 (CC/CT)- rs11165675 (GA/AA)- rs543874 (GG/GA)	1.96 (0.90, 4.26)	0.09
8	rs11030104 (AG/GG)- rs11191580 (CC/CT)- rs11165675 (GG)	2.78 (1.29, 5.98)	<0.01
3	rs11030104 (AG/GG)- rs11191580 (TT)	2.74 (1.55, 4.85)	<0.01
6	rs11030104 (AA)- rs10913469 (CC/CT)	5.31 (2.52, 11.20)	<0.01
5	rs11030104 (AA)- rs10913469 (TT)	2.51 (1.33, 4.76)	<0.01

Note: ORs of terminal nodes were calculated by unconditional multivariable logistic regression analysis, adjusting for child gender, BMI_Z at birth, feeding pattern in the 1-month old, weight gain velocity from birth to 3-month old, gestational weight gain, and parental BMI. CART: the classification and regression tree.