Associations between Gene-Gene Interaction and Overweight/Obesity of 12-Month-Old Chinese Infants
Table 2
Associations between each SNP and risk for overweight/obesity at 12-month-old infants.
Characteristics
Model 1 unadjusted analysis
Model 2 adjusted analysis a
Model 3 adjusted analysis b
OR (95% CI)
OR (95% CI)
OR (95% CI)
SEC16B rs543874
0.02
0.01
0.01
AA
1
1
1
GG+GA
1.48 (1.05, 2.08)
1.57 (1.11, 2.23)
1.58 (1.11, 2.24)
SEC16B rs10913469
0.09
0.11
0.11
TT
1
1
1
CC+CT
1.34 (0.96, 1.87)
1.32 (0.94, 1.85)
1.32 (0.94, 1.86)
BDNF rs11030104
0.02
0.03
0.03
AG+GG
1
1
1
AA
1.53 (1.08, 2.18)
1.50 (1.04, 2.14)
1.48 (1.03, 2.12)
BDNF rs6265
0.05
0.09
0.10
CT+TT
1
1
1
CC
1.43 (1.00, 2.04)
1.38 (0.96, 2.99)
1.36 (0.94, 1.98)
NT5C2 rs11191580
0.04
0.09
0.06
TT
1
1
1
CC+CT
0.71 (0.52, 0.98)
0.75 (0.54, 1.04)
0.73 (0.52, 1.02)
PTBP2 rs11165675
0.06
0.11
0.08
GA+AA
1
1
1
GG
1.43 (0.99, 2.07)
1.36 (0.93, 1.99)
1.40 (0.96, 2.06)
ADCY9 rs2531995
0.13
0.12
0.18
TT
1
1
1
CC+CT
0.68 (0.41, 1.11)
0.67 (0.40, 1.11)
0.70 (0.42, 1.17)
FAM120A rs7869969
0.33
0.43
0.40
AG+GG
1
1
1
AA
0.84 (0.59, 1.20)
0.87 (0.60, 1.24)
0.86 (0.60, 1.23)
KCNQ1 rs2237892
0.23
0.18
0.24
CT+TT
1
1
1
CC
0.82 (0.59, 1.13)
0.80 (0.57, 1.11)
0.82 (0.58, 1.14)
C4orf33 rs2968990
0.18
0.35
0.37
TT
1
1
1
CC+CT
1.34 (0.88, 2.05)
1.23 (0.80, 1.89)
1.22 (0.79, 1.88)
Notes: the unconditional multivariable logistic regression models were adopted; aadjusted for child gender, feeding pattern in the 1-month old, weight gain velocity from birth to 3-month old; badjusted for all variables of Model 2, including BMI_Z at birth, gestational weight gain. and parental BMI.
