Exploring Molecular Mechanisms Involved in the Development of the Depression-Like Phenotype in Interleukin-18-Deficient Mice

Table 2

Disease association or functional annotation based on ingenuity pathway analysis.

Disease or function annotation	value	Molecules
Disruption of blood-brain barrier	≤0.001	C3, Kng1
Inflammatory response of the cerebral cortex	0.001	Kng1
Diameter of basilar artery	0.001	Kng1
Inflammatory response	0.001	C3, Kng1
Cellular homeostasis	0.001	C5, Kng1
First-onset paranoid schizophrenia	0.002	TTR
Liberation of arachidonic acid	0.002	Kng1
Infiltration by CD3-positive T lymphocytes	0.002	C5
Accumulation of microglia	0.002	C5
Liberation of stearic acid	0.002	Kng1
Cellular infiltration of dendritic cells	0.002	C5
Thrombus	0.002	Kng1
Immune response of the brain	0.002	C3, Kng1
Size of infarct	0.003	C3, Kng1
Brain damage	0.005	C5, Kng1
Damage of blood-brain barrier	0.007	Kng1
Abnormal morphology of the hippocampal CA3 region	0.007	C3
Concentration of arachidonic acid	0.008	Kng1
Alzheimer disease	0.010	C3, Ttr
Flow of blood	0.016	Kng1
Edema of the brain	0.019	Kng1
Quantity of amyloid fibrils	0.019	C3
Apoptosis	0.020	C5, Ttr
Damage of brain cells	0.022	C5
Permeability of blood-brain barrier	0.022	Kng1
Cell viability of granule cells	0.025	C5
Disorder of the basal ganglia	0.032	C3, Kng1
Neurodegeneration of the cerebellum	0.036	C3
Volume of infarct	0.045	Kng1
Loss of neurons in the central nervous system	0.047	Ttr