Exploring Molecular Mechanisms Involved in the Development of the Depression-Like Phenotype in Interleukin-18-Deficient Mice

Figure 1

Interleukin- (IL-) 18 expression in the prefrontal cortex (PFC) of a healthy control and a major depressive disorder patient. Immunofluorescence staining was used to evaluate IL-18 expression in the PFC. IL-18 (green), microtubule-associated protein 2 (MAP2) (red), 4,6-diamidino-2-phenylindole (DAPI) (blue), and merged pictures are shown. Cells positive for both IL-18 and MAP2 were present in the human PFC. Scale bars represent 20 μm. HC: healthy control; MDD: major depressive disorder.