Relationship between CRP Albumin Ratio and the Mortality in Critically Ill Patients with AKI: A Retrospective Observational Study
Table 3
Effect size of CAR on hospital mortality in prespecified and exploratory subgroups in each subgroup.
CRP to albumin ratio (CAR)
0-0.2
0.21-2.53
2.54-16.43
OR (95% CIs)
trend
OR (95% CIs)
trend
Gender
Male
1.0 (ref)
1.5 (0.8, 2.8)
0.223
2.9 (1.6, 5.2)
<0.001
Female
1.0 (ref)
2.2 (0.8, 6.0)
0.116
5.4 (2.1, 13.9)
<0.001
Recovery from AKI
Yes
1.0 (ref)
1.3 (0.7, 2.4)
0.414
2.3 (1.3, 4.3)
0.007
No
1.0 (ref)
3.7 (1.3, 10.7)
0.017
8.2 (3.0, 22.6)
<0.001
Age (year)
<52
1.0 (ref)
1.7 (0.6, 4.8)
0.326
3.5 (1.2, 10.2)
0.019
≥53, <66
1.0 (ref)
2.2 (0.8, 5.8)
0.110
4.6 (1.9, 10.9)
<0.001
≥67
1.0 (ref)
1.4 (0.6, 3.2)
0.418
2.5 (1.2, 5.3)
0.017
Respiratory rate (beats/minute)
<18
1.0 (ref)
3.2 (0.7, 14.5)
0.133
8.2 (2.2, 30.9)
0.002
≥18, <20
1.0 (ref)
2.1 (0.7, 5.9)
0.158
3.4 (1.1, 10.0)
0.028
≥20
1.0 (ref)
1.2 (0.6, 2.4)
0.542
2.8 (1.5, 5.3)
0.001
BUN (mmol/L)
<5.6
1.0 (ref)
1.7 (0.7, 4.3)
0.230
3.9 (1.7, 9.1)
0.001
≥5.6, <9.4
1.0 (ref)
1.8 (0.7, 4.6)
0.206
3.9 (1.7, 9.4)
0.002
≥9.4
1.0 (ref)
1.4 (0.6, 3.6)
0.474
2.8 (1.2, 6.9)
0.022
Creatinine (μmol/L)
<140.09
1.0 (ref)
1.6 (0.6, 4.3)
0.388
6.1 (2.5, 15.2)
<0.001
≥140.09, <207
1.0 (ref)
2.4 (1.0, 5.9)
0.055
3.9 (1.7, 9.2)
0.002
≥207
1.0 (ref)
1.1 (0.5, 2.6)
0.803
2.0 (0.9, 4.5)
0.109
Sodium (mmol/L)
<138
1.0 (ref)
1.4 (0.5, 3.8)
0.509
3.1 (1.1, 8.3)
0.028
≥138, <141
1.0 (ref)
1.8 (0.7, 4.9)
0.226
3.5 (1.4, 8.9)
0.009
≥141
1.0 (ref)
1.4 (0.6, 3.2)
0.478
3.4 (1.6, 7.2)
<0.001
Potassium (mmol/L)
<3.9
1.0 (ref)
2.4 (0.7, 8.1)
0.144
6.3 (2.0, 19.7)
0.001
≥3.9, <4.3
1.0 (ref)
1.6 (0.7, 3.7)
0.267
2.8 (1.2, 6.4)
0.015
≥4.3
1.0 (ref)
1.7 (0.7, 3.9)
0.236
3.4 (1.6, 7.6)
0.002
RBC (1012/L)
<3.71
1.0 (ref)
2.2 (0.7, 7.4)
0.180
5.2 (1.7, 16.2)
0.004
≥3.71, <4.5
1.0 (ref)
1.5 (0.6, 3.5)
0.360
3.5 (1.6, 8.0)
0.002
≥4.5
1.0 (ref)
2.3 (0.9, 5.9)
0.074
3.9 (1.6, 9.6)
0.002
WBC (109/L)
<6.17
1.0 (ref)
1.8 (0.7, 4.2)
0.203
4.9 (2.1, 11.4)
<0.001
≥6.17, <10.36
1.0 (ref)
1.9 (0.8, 4.5)
0.150
2.5 (1.1, 5.8)
0.030
≥10.36
1.0 (ref)
3.7 (0.8, 17.3)
0.098
9.6 (2.2, 42.9)
0.003
Glucose (mmol/L)
<5.35
1.0 (ref)
2.0 (0.9, 4.7)
0.099
1.9 (0.8, 4.4)
0.125
≥5.35, <7.65
1.0 (ref)
1.1 (0.4, 2.9)
0.776
3.2 (1.3, 8.0)
0.011
≥7.65
1.0 (ref)
2.5 (0.8, 7.5)
0.098
6.1 (2.2, 17.0)
<0.001
Hematocrit (%)
<33.4
1.0 (ref)
2.0 (0.7, 6.1)
0.203
4.2 (1.5, 11.8)
0.007
≥33.4, <40.2
1.0 (ref)
1.4 (0.6, 3.3)
0.398
3.1 (1.3, 7.0)
0.008
≥40.2
1.0 (ref)
2.5 (0.9, 6.6)
0.067
5.6 (2.3, 13.6)
<0.001
Hemoglobin (g/L)
<110
1.0 (ref)
2.8 (0.9, 9.1)
0.081
4.2 (1.4, 13.2)
0.013
≥110, <136
1.0 (ref)
1.1 (0.5, 2.6)
0.754
3.2 (1.5, 7.1)
0.004
≥136
1.0 (ref)
2.7 (1.0, 7.4)
0.052
6.7 (2.7, 17.1)
<0.001
MCV (fL)
<87.3
1.0 (ref)
1.8 (0.7, 4.6)
0.253
3.1 (1.2, 8.1)
0.023
≥87.3, <92.1
1.0 (ref)
1.7 (0.7, 4.0)
0.240
4.2 (1.8, 9.5)
<0.001
≥92.1
1.0 (ref)
2.4 (0.9, 6.7)
0.097
5.2 (2.1, 12.8)
<0.001
Triglycerides (mmol/L)
<1.04
1.0 (ref)
2.8 (0.9, 8.3)
0.065
9.9 (3.5, 28.0)
<0.001
≥1.04, <1.68
1.0 (ref)
1.3 (0.6, 3.0)
0.483
1.5 (0.6, 3.3)
0.371
≥1.68
1.0 (ref)
1.7 (0.6, 4.7)
0.328
4.0 (1.6, 10.1)
0.004
TBIL (μmol/L)
<11.9
1.0 (ref)
1.0 (0.4, 2.4)
0.956
1.7 (0.7, 3.8)
0.220
≥11.9, <19.3
1.0 (ref)
2.0 (0.8, 4.9)
0.111
4.5 (1.9, 10.6)
<0.001
≥19.3
1.0 (ref)
2.5 (0.8, 7.6)
0.095
6.5 (2.3, 18.4)
<0.001
RDW (%)
<13.2
1.0 (ref)
2.6 (1.0, 6.9)
0.059
4.7 (1.9, 11.3)
<0.001
≥13.2, <14.2
1.0 (ref)
1.5 (0.6, 3.9)
0.347
4.2 (1.8, 10.2)
0.001
≥14.2
1.0 (ref)
1.7 (0.7, 4.5)
0.269
3.4 (1.3, 8.5)
0.010
BMG (mg/L)
<2.31
1.0 (ref)
2.3 (1.0, 5.5)
0.065
3.9 (1.7, 9.0)
0.001
≥2.31, <3.69
1.0 (ref)
1.6 (0.7, 4.0)
0.288
3.5 (1.5, 8.2)
0.004
≥3.69
1.0 (ref)
1.3 (0.5, 3.5)
0.611
3.2 (1.3, 8.2)
0.013
ICU LOS (days)
<4
1.0 (ref)
2.9 (1.1, 7.7)
0.035
3.7 (1.4, 10.0)
0.010
≥4, <10
1.0 (ref)
2.7 (1.1, 6.9)
0.039
5.1 (2.0, 12.9)
<0.001
≥10
1.0 (ref)
0.6 (0.3, 1.5)
0.303
1.9 (0.9, 4.1)
0.096
Surgical grade
No surgery or grade 1
1.0 (ref)
1.7 (0.8, 3.9)
0.192
4.1 (1.8, 9.4)
<0.001
Grade 2
1.0 (ref)
0.0 (0.0, Inf)
0.991
1.4 (0.4, 5.5)
0.617
Grade 3
1.0 (ref)
0.9 (0.1, 6.5)
0.908
0.4 (0.0, 5.0)
0.512
Grade 4
1.0 (ref)
3.5 (1.2, 10.1)
0.021
7.8 (2.9, 21.0)
<0.001
CRP: C-reactive protein; BUN: blood urea nitrogen; RBC: red blood cells; WBC: white blood cell; MCV: mean corpuscular volume; TBIL: total bilirubin; RDW: red cell distribution width; BMG: β2-microglobulin; ICU: intensive care unit; LOS: length of stay.
