Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice

Figure 4

Intraperitoneal injection of PIH significantly inhibited ferroptosis in brain tissue around hematoma. (a) Total iron concentration was detected by tissue iron assay kit (). (b) Tissue ROS levels were evaluated by tissue ROS detecting kit using the BB cell Probe™O12 reactive oxygen probe (). (c) MDA activity was measured with lipid peroxidation MDA assay kit (). (d–f) Western blotting analysis of GPX4 and COX2 expression in ICH mice (, , ).. The data are presented as . , ; ns: not significant.

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