ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in Melanoma

<div>ZC3H15 is upregulated in human melanoma and is a prognostic indicator for melanoma patients. (a) Representative immunohistochemical staining assays of ZC3H15 expression in human melanoma (right) and benign tissue (left). (b) Immunohistochemistry analyses of ZC3H15 expression levels in 8 benign tissue samples and 15 melanoma samples. (c) Kaplan-Meier analysis of progression-free survival using data from the Tumor Glioma-kawaguchi-50 database and Tumor Glioma-French-284 database with the log-rank test <svg height="8.68572pt" id="M23" style="vertical-align:-0.0498209pt" version="1.1" viewbox="-0.0498162 -8.6359 8.15071 8.68572" width="8.15071pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g></svg> values indicated. (d, e) Quantitative PCR assays and western blot assays were performed to detect the expression of ZC3H15 in melanoma cell lines A375, MV3, and Skmel28, as well as human melanocyte cell line PIG1. 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BioMed Research International

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Figure 1

Figure 1: ZC3H15 Correlates with a Poor Prognosis and Tumor Progression in Melanoma 