Review Article

Dysregulation of lncRNA in Helicobacter pylori-Infected Gastric Cancer Cells

Table 1

Subtypes of lncRNA introduced according to the recent studies.

NameLength (nt)FunctionExampleReferences

Intergenic828Control the expression of both near and remote genesLINC00152, H19, IPW, MEG3[3537]
IntragenicAttach to promoters and enhancersRUNXOR[35, 39]
EnhancerSpecific enhancer–promoter looping, gene expressionIG-DMR eRNAs[35, 56]
AntisenseGene regulation, X-inactivation, imprinting, and epigenetic regulationKCNQ1OT1, AIRN, NESPAS, Ube3a-ATS, ANRIL[4244]
sno-lncRNAsContribute in the pathogenesis of PWS[4244]
circRNAsUnder 100 nt to over 4 kbRelated with disease phenotypecANRIL[4245]
ciRNAsGene transcription[4245]

lncRNAs: long noncoding RNAs; LINC00152: long intergenic non-protein-coding RNA152; IPW: imprinted gene in the Prader-Willi syndrome region; MEG3: maternally expressed gene 3; RUNXOR: RUNX1 overlapping RNA; IG-DMR: intergenic differentially methylated region; KCNQ1OT1: KCNQ1 opposite strand/antisense transcript 1; AIRN: antisense of insulin-like growth factor-2 receptor RNA noncoding; UBE3A-ATS: UBE3A antisense transcript; ANRIL: antisense noncoding RNA in the INK4 locus.