Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset

<div>Top Kyoto Encyclopedia of Genes and Genomes pathways regulated by candidate target genes of significantly differentially expressed microRNAs. (a) HC vs. DM-ILD-MDA5 Ab(+). (b) DM-nonILD-MSA16(-) vs. DM-ILD-MDA5 Ab(+). (c) HC vs. DM-nonILD-MSA16(-). HCs: healthy controls; DM-ILD-MDA5 Ab(+): DM patients with ILDs and anti-melanoma differentiation-associated protein 5 antibody-positive status; DM-nonILD-MSA16(-): DM patients without ILDs who were negative for 16 detectable myositis-specific antibodies; ILD: interstitial lung disease; DM: dermatomyositis; PKG: protein kinase G; Fox: forkhead box; cGMP: cyclic guanosine monophosphate; cAMP: cyclic adenosine monophosphate; HTLV: human T-lymphotropic virus.</div>

BioMed Research International

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Figure 6

Figure 6: Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset 

Figure 6 | Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset 