Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset

Figure 4

Heatmaps of the top 50 significantly differentially expressed miRNAs between pairs of groups. (a) HC vs. DM-ILD-MDA5 Ab (+), (b) DM-nonILD-MSA16 (-) vs. DM-ILD-MDA5 Ab(+), and (c) HC vs. DM-nonILD-MSA16(-). Gene expression data were obtained using next-generation sequencing on the Illumina HiSeq 2500 platform. The miRNAs are displayed on the vertical axis and the different numbered subjects on the horizontal axis. HCs: healthy controls; DM-ILD-MDA5 Ab(+): DM patients with ILDs and anti-melanoma differentiation-associated protein 5 antibody-positive status; DM-nonILD-MSA16(-): DM patients without ILDs who were negative for 16 detectable myositis-specific antibodies; ILD: interstitial lung disease; DM: dermatomyositis; miRNA/miR: microRNA; hsa: Homo sapiens.

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