Research Article
[Retracted] Agomelatine Softens Depressive-Like Behavior through the Regulation of Autophagy and Apoptosis
Figure 2
Effect of AGO treatment on BDNF/TrkB and pERK1/2 in autophagy, apoptosis, and inflammation in CRS mice. (a) Representative western blot results of BDNF, TrkB, and pERK1/2 are shown; densitometry analysis of BDNF (b), TrkB (c), and pERK1/2 (d) in the hippocampus is presented. (e) Representative western blot results of LC3II, Beclin1, and p62 are shown; densitometry analysis of Beclin1 (f), LC3II (g), and p62 (h) in the hippocampus. (i) Representative western blot results of Bcl2 and Bax are shown; (j) densitometry analysis of the Bcl2/Bax ratio in the hippocampus. (k) Representative western blot results of NF-κB/p65, iNOS, and nNOS; densitometry analysis of NF-κB/p65 (l), iNOS (m), and nNOS (n) in the hippocampus. ; ; ; ns = not significant. The values represent . -5.
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