Research Article

Identification of Key Biomarkers and Pathways in Small-Cell Lung Cancer Using Biological Analysis

Table 1

268 DEG lists were identified and confirmed from three GEO datasets.

RegulationNumberGenes

Upregulation192TPX2, GF2BP3, CCNB1, PCSK1, CXCL13, GINS1, ZIC2, ISL1, ANLN, BIRC5, KCNC1, KNTC1, CCNE1, FOXM1, CDK1, RACGAP1, TOX3, CDC6, CENPU, CEL, AURKA, KIF14, MAD2L1, ZNF711, RNF182, IGSF9, ELAVL2, KIF4A, MCM10, TYMS, DNA2, MELK, ZWINT, NDC80, PPM1E, OIP5, CCNA2, GTSE1, POU3F2, NUF2, PTTG1, NRTN, MMP12, CDCA5, UBE2T, CKS2, FOXG1, ECT2, DEPDC1, KIF23, NOL4, CENPE, SPAG5, TUBB2B, INSM1, HOXD10, CCNB2, PRC1, SRD5A1, CDT1, CENPW, CEP55, PLEKHG4B, CCNE2, CDC45, PMAIP1, MCM2, MCM4, INHBE, SBK1, DLGAP5, RAD51AP1, SCG3, KIF1A, CKAP2L, MKI67, CDCA2, CDCA8, EXO1, GRP, C12orf56, FZD3, NMU, RGS17, CENPK, LOC646903, UGT8, NEK2, SOX2, GINS2, ESPL1, DONSON, AMER2, E2F8, MEX3B, DEPDC1B, CLGN, DSP, SOX4, ADAMDEC1, UCHL1, EZH2, NUP62CL, CHEK1, NEIL3, KIF11, KIF18B, ASF1B, RIPPLY3, CDH2, KIFC1, FOXO6, DLX6, NCAPG2, KIF2C, GNG4, FBXO5, C5orf34, HAGLROS, CDCA7, CDC20, RFC4, MIAT, BUB1, PBK, AP3B2, SKA1, TRIP13, CDC7, NCAPH, ACYP1, SMC2, RMI1, ASPM, CDCA3, ATAD2, BRIP1, ELAVL4, STIL, UBE2C, MND1, NELL1, RAB3B, HES6, POLE2, RRM2, TOP2A, FEN1, HELLS, FANCI, RAD54L, DLX5, ZNF367, SPC25, KIF18A, DDC, KIF15, BUB1B, HJURP, DTL, FAM83D, CENPV, MEST, HMMR, NRCAM, RIMS2, GMNN, KIF20A, ORC6, KCNMB2, SOX11, SIX1, HEPACAM2, ASCL1, PEX5L, SGO2, CDKN2A, IGFBPL1, LHX2, ONECUT2, TTK, CDKN3, GAD1, NCAPG, RASSF6, CELF4, RMI2, RNF183, CENPF, NUSAP1, ELAVL3, ST18
Downregulation76FIBIN, PPP1R14A, GHR, MAOA, GDF10, LAMP3, FCN1, HLF, FHL1, RRAD, SCN4B, SFTPD, PLAC9, FHL5, GPM6A, NR3C2, EMCN, GPIHBP1, OGN, SCGB1A1, CA4, AQP3, LYVE1, ADAMTS8, NAPSA, ADIRF, SRPX, RNASE1, SFTPC, FXYD1, FOSB, RSPO3, CX3CR1, WFDC1, BMP5, AOX1, CFD, RNASE4, CHRDL1, DPP4, MUC1, CD36, SERPINA1, TNNC1, ABCA8, STEAP4, AOC3, FCER1A, ZBTB16, ASPA, FGFR2, EDNRB, C7, DPT, MFAP4, SCARA5, MAOB, PTGDS, CDO1, ADAMTS1, S1PR1, NEXN, CA2, SFTPB, ANPEP, AQP1, RBMS3, ADH1B, NEDD9, CXCL5, FABP4, FAM107A, GPX3, SCGB3A2, GPAT3, FBLN5