[Retracted] Celastrol Attenuates Learning and Memory Deficits in an Alzheimer’s Disease Rat Model

Figure 3

Celastrol inhibited Aβ_25-35-induced NF-κB signalling pathway activation. (a–c) Quantitative analysis using western blot showed that cytoplasmic p-p65 expression and nuclear p65 levels were significantly downregulated by CEL. Data are represented as (). vs. sham group and ^# vs. Aβ_25-35 group. (a, d, e) CEL markedly upregulated IKBα expression and decreased p-IKBα levels. Data are represented as (). and vs. sham group and ^# vs. Aβ_25-35 group. (a, f). CEL markedly downregulated iNOS expression in CA1 region. Data are represented as (). and compared with the sham group and ^# vs. Aβ_25-35 group. (g) ELISA assay showing a more pronounced decrease of NF-κB p65-DNA binding in CEL group. and compared with the sham group and ^# vs. Aβ_25-35 group. Data are represented as ().

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