Increased Expression of TIGIT/CD57 in Peripheral Blood/Bone Marrow NK Cells in Patients with Chronic Myeloid Leukemia

Figure 2

DN-CML BM NK cells had a significantly increased level of CD57 compared to NK cells in the BM from HIs. (a) Differences in the mean proportion of immunophenotypes in the BM from HIs () and age-matched PB from HIs (; median age: 38; range: 21-51) are shown. The height of the bar signifies the amplitude of the difference between BM and PB samples (the PB median value is subtracted from the BM median value). The green bars above the axis represent immunophenotypes more prevalent in PB than BM samples. values were computed using the nonparametric Mann–Whitney test between two groups. (b) The NK subset populations and expression of immunophenotypes in NK subsets from PB and matched BM from eight DN-CML patients. As the PB and BM were collected from the same patients, values were computed using the parametric Mann–Whitney test between two groups. (c) Frequency of CD57⁺, CD57⁺CD56^bright, and CD57⁺CD56^dim NK cells from HI BM () and BM from 7 patients with DN-CML (). (d) Model illustrating the phenotypic differences of NK cells for BM and PB in HIs and BM and PB in DN-CML patients. All data are shown as . There is a significant difference between the two groups connected by the blue lines. Significance levels were defined as ns (not significant, ). values < 0.05 were indicated as significant.

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